The health effects of vitamin D supplementation: evidence from human studies

R Bouillon, D Manousaki, C Rosen… - Nature Reviews …, 2022 - nature.com
Vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …

Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

An update on vitamin D metabolism

F Saponaro, A Saba, R Zucchi - International journal of molecular …, 2020 - mdpi.com
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone
homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been …

RETRACTED: Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian …

E Sofianopoulou, SK Kaptoge, S Afzal… - The Lancet Diabetes & …, 2021 - thelancet.com
Background Randomised trials of vitamin D supplementation for cardiovascular disease and
all-cause mortality have generally reported null findings. However, generalisability of results …

Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue …

P Lips, KD Cashman, C Lamberg-Allardt… - European journal of …, 2019 - academic.oup.com
Vitamin D deficiency (serum 25-hydroxyvitamin D (25 (OH) D)< 50 nmol/L or 20 ng/mL) is
common in Europe and the Middle East. It occurs in< 20% of the population in Northern …

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐and middle‐income countries

DE Roth, SA Abrams, J Aloia, G Bergeron… - 2018 - Wiley Online Library
Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory
illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many …

[HTML][HTML] Vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions

DD Bikle, J Schwartz - Frontiers in endocrinology, 2019 - frontiersin.org
This review focuses on the biologic importance of the vitamin D binding protein (DBP) with
emphasis on its regulation of total and free vitamin D metabolite levels in various clinical …

New aspects of vitamin D metabolism and action—Addressing the skin as source and target

D Bikle, S Christakos - Nature Reviews Endocrinology, 2020 - nature.com
Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Environmental and genetic risk factors for MS: an integrated review

E Waubant, R Lucas, E Mowry, J Graves… - Annals of clinical …, 2019 - Wiley Online Library
Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …