Optogenetics ushered in a revolution in how neuroscientists interrogate brain function.
Because of technical limitations, the majority of optogenetic studies have used low spatial …

The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …

We describe an all-optical strategy for simultaneously manipulating and recording the
activity of multiple neurons with cellular resolution in vivo. We performed simultaneous two …

Genetically encoded, single-component optogenetic tools have made a significant impact on
neuroscience, enabling specific modulation of selected cells within complex neural tissues …

Optogenetic approaches promise to revolutionize neuroscience by using light to manipulate
neural activity in genetically or functionally defined neurons with millisecond precision …

A great challenge in neuroscience is understanding how activity in the brain gives rise to
behavior. The zebrafish is an ideal vertebrate model to address this challenge, thanks to the …

In vivo optogenetic strategies have redefined our ability to assay how neural circuits govern
behavior. Although acutely implanted optical fibers have previously been used in such …

A significant challenge for neuroscientists is to determine how both electrical and chemical
signals affect the activity of cells and circuits and how the nervous system subsequently …

We demonstrate a two-photon optogenetic method that generates action potentials in
neurons with single-cell precision, using the red-shifted opsin C1V1T. We applied the …

This review, one of a series of articles, tries to make sense of optogenetics, a recently
developed technology that can be used to control the activity of genetically-defined neurons …