Norovirus infections and disease in lower-middle-and low-income countries, 1997–2018

J Mans - Viruses, 2019 - mdpi.com
Noroviruses are a major cause of viral gastroenteritis. The burden of the norovirus in low-
resource settings is not well-established due to limited data. This study reviews the norovirus …

Advances in human norovirus vaccine research

M Zhang, M Fu, Q Hu - Vaccines, 2021 - mdpi.com
Human norovirus (HuNoV) is the leading cause of acute gastroenteritis (AGE) worldwide,
which is highly stable and contagious, with a few virus particles being sufficient to establish …

Immune imprinting drives human norovirus potential for global spread

LC Lindesmith, FAT Boshier, PD Brewer-Jensen, S Roy… - MBio, 2022 - Am Soc Microbiol
Understanding the complex interactions between virus and host that drive new strain
evolution is key to predicting the emergence potential of variants and informing vaccine …

Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII. 4 noroviruses

JA Kendra, K Tohma, LA Ford-Siltz… - Proceedings of the …, 2021 - National Acad Sciences
Noroviruses are the predominant cause of acute gastroenteritis, with a single genotype (GII.
4) responsible for the majority of infections. This prevalence is characterized by the periodic …

Population genomics of GII. 4 noroviruses reveal complex diversification and new antigenic sites involved in the emergence of pandemic strains

K Tohma, CJ Lepore, Y Gao, LA Ford-Siltz, GI Parra - MBio, 2019 - Am Soc Microbiol
ABSTRACT GII. 4 noroviruses are a major cause of acute gastroenteritis. Their dominance
has been partially explained by the continuous emergence of antigenically distinct variants …

GII. 4 human norovirus: surveying the antigenic landscape

ML Mallory, LC Lindesmith, RL Graham, RS Baric - Viruses, 2019 - mdpi.com
Human norovirus is the leading cause of viral acute onset gastroenteritis disease burden,
with 685 million infections reported annually. Vulnerable populations, such as children …

The antigenic topology of norovirus as defined by B and T cell epitope mapping: implications for universal vaccines and therapeutics

JM van Loben Sels, KY Green - Viruses, 2019 - mdpi.com
Human norovirus (HuNoV) is the leading cause of acute nonbacterial gastroenteritis.
Vaccine design has been confounded by the antigenic diversity of these viruses and a …

Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response

L Su, W Huang, FH Neill, MK Estes, RL Atmar… - npj Vaccines, 2023 - nature.com
Human noroviruses (HuNoV) are the leading cause of acute gastroenteritis worldwide. The
humoral immune response plays an important role in clearing HuNoV infections and …

Immune response modulation by caliciviruses

Y Peñaflor-Téllez, A Trujillo-Uscanga… - Frontiers in …, 2019 - frontiersin.org
Noroviruses and Sapoviruses, classified in the Caliciviridae family, are small positive-
stranded RNA viruses, considered nowadays the leading cause of acute gastroenteritis …

Genomic analysis of human noroviruses using combined Illumina–Nanopore data

A Flint, S Reaume, J Harlow, E Hoover… - Virus …, 2021 - academic.oup.com
Whole-genome sequence analysis of noroviruses is routinely performed by employing a
metagenomic approach. While this methodology has several advantages, such as allowing …