Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …

The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells,
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …

Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …

Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse
neurodegenerative diseases. Current in vitro and in vivo approaches support that …

Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …

Background The aging process is not univocal, both body and brain age. Neurological
disorders are a major cause of disability and death worldwide. According to the Global …