Advances in laser speckle imaging: from qualitative to quantitative hemodynamic assessment

MM Qureshi, N Allam, J Im, HS Kwon… - Journal of …, 2024 - Wiley Online Library
Laser speckle imaging (LSI) techniques have emerged as a promising method for
visualizing functional blood vessels and tissue perfusion by analyzing the speckle patterns …

Evaluation of the clinical relevance and limitations of current pre-clinical models of peripheral artery disease

SM Krishna, SM Omer, J Golledge - Clinical science, 2016 - portlandpress.com
Peripheral arterial disease (PAD) usually results from atherosclerosis and associated
thrombosis and limits blood supply to the lower limbs. Common presenting symptoms …

Transmissive-detected laser speckle contrast imaging for blood flow monitoring in thick tissue: from Monte Carlo simulation to experimental demonstration

DY Li, Q Xia, TT Yu, JT Zhu, D Zhu - Light: Science & Applications, 2021 - nature.com
Laser speckle contrast imaging (LSCI) is a powerful tool to monitor blood flow distribution
and has been widely used in studies of microcirculation, both for animal and clinical …

Mechanisms of amplified arteriogenesis in collateral artery segments exposed to reversed flow direction

JL Heuslein, JK Meisner, X Li, J Song… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Collateral arteriogenesis, the growth of existing arterial vessels to a larger
diameter, is a fundamental adaptive response that is often critical for the perfusion and …

Exposure of endothelium to biomimetic flow waveforms yields identification of miR-199a-5p as a potent regulator of arteriogenesis

JL Heuslein, CM Gorick, SP McDonnell, J Song… - … Therapy-Nucleic Acids, 2018 - cell.com
Arteriogenesis, the growth of endogenous collateral arteries bypassing arterial occlusion (s),
is a fundamental shear stress-induced adaptation with implications for treating peripheral …

Effect of skin optical absorption on speckleplethysmographic (SPG) signals

TB Rice, B Yang, S White - Biomedical Optics Express, 2020 - opg.optica.org
Recent advances in optical technology have emerged for measuring blood flow in the
extremities using speckleplethysmography (SPG), which may address needs in vascular …

Estimating hemodynamic shear stress in murine peripheral collateral arteries by two-photon line scanning

M Lasch, K Nekolla, AH Klemm, JI Buchheim… - Molecular and Cellular …, 2019 - Springer
Abstract Changes in wall shear stress of blood vessels are assumed to be an important
component of many physiological and pathophysiological processes. However, due to …

DNA methyltransferase 1–dependent DNA hypermethylation constrains arteriogenesis by augmenting shear stress set point

JL Heuslein, CM Gorick, J Song… - Journal of the American …, 2017 - Am Heart Assoc
Background Arteriogenesis is initiated by increased shear stress and is thought to continue
until shear stress is returned to its original “set point.” However, the molecular mechanism (s) …

Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development

K Ramo, K Sugamura, S Craige, JF Keaney Jr… - Elife, 2016 - elifesciences.org
Arterial occlusive diseases are major causes of morbidity and mortality. Blood flow to the
affected tissue must be restored quickly if viability and function are to be preserved. We …

Dual-exposure temporal laser speckle imaging for simultaneously accessing microvascular blood perfusion and angiography

R Li, M Ma, C Wang, J Hong, Z Zhang, J Lu, P Li - Optics Express, 2024 - opg.optica.org
Laser speckle contrast imaging (LSCI) has gained significant attention in the biomedical
field for its ability to map the spatio-temporal dynamics of blood perfusion in vivo. However …