Wound healing is a complex and dynamic biological process that involves the coordinated
efforts of multiple cell types and is executed and regulated by numerous growth factors and …

An estimated 15% of patients with diabetes mellitus will develop a foot ulcer during their
lifetime. Debridement is included in multiple guidelines and algorithms for the care of …

Infection is a major co-morbidity that contributes to impaired healing in diabetic wounds.
Although impairments in diabetic neutrophils have been blamed for this co-morbidity, what …

Persistent inflammation is a major contributor to healing impairment in diabetic chronic
wounds. Paradoxically, diabetic wound environment during the acute phase of healing is …

Staphylococcus aureus and Staphylococcus epidermidis biofilms cause chronic infections
due to their ability to form biofilms. The excretions/secretions of Lucilia sericata larvae …

Diabetic chronic ulcers are plagued with persistent nonresolving inflammation. However,
diabetic wound environment early after injury suffers from inadequate inflammatory …

Background: Guidelines recommend both histological analysis and culture for definite
diagnosis of osteomyelitis. It is not clear if histological and culture criteria can be used …

ABSTRACT A critical question in the treatment of chronic wounds is whether and when
debridement is needed. The three most common chronic wounds are the diabetic foot ulcer …

The larvae of Lucilia sericata (the medicinal maggot) have been exploited to undertake
many applications, from their use in the management of chronic, non-healing wounds (larval …

Macrophages play an important role in tissue repair, regeneration, and the ability of
biomaterials to mediate these processes. Macrophages are highly plastic cells that exhibit …