Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely
overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an …

Abstract 11C-BU99008 is a novel positron emission tomography (PET) tracer that enables
selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated …

COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with
a broad spectrum of clinical manifestations. The evolving scientific and clinical evidence …

After brain injuries, concentrations of some brain markers such as S100B protein in serum
and cerebrospinal fluid (CSF) are correlated with the severity and outcome of brain damage …

The brain is an organ in which energy metabolism occurs most intensively and glucose is an
essential and dominant energy substrate. There have been many studies in recent years …

Background The striking increase in COVID-19 severity in older adults provides a clear
example of immunesenescence, the age-related remodelling of the immune system. To …

The ε4 polymorphism of the APOE gene confers a substantially increased risk of developing
Alzheimer's disease. However, the influence of the ε4 allele on age-related cognitive …

S100B, a biomarker of glial dysfunction and blood-brain barrier (BBB) disruption, has been
proposed to be involved in the pathophysiology of schizophrenia. In the present study, we …

Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are comorbidities that result
from the sharing of common genes. The molecular background of comorbidities can provide …