As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …

Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant
progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has …

Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

Breast cancer is one of the most common malignancies among women throughout the world
and is the major cause of most cancer-related deaths. Several explanations account for the …

The lysyl oxidase family represents a promising target in stromal targeting of solid tumors
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …