Chimeric antigen receptor (CAR) T cell therapy has garnered significant excitement due to
its success for hematological malignancies in clinical studies leading to the US Food and …

Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in
normal tissues, making most subtypes unsuitable as targets for cancer therapy. However …

Locoregional delivery of chimeric antigen receptor (CAR) T cells has resulted in objective
responses in adults with glioblastoma, but the feasibility and tolerability of this approach is …

Anti-NMDA receptor (NMDAR) autoantibodies cause NMDAR encephalitis, the most
common autoimmune encephalitis, leading to psychosis, seizures, and autonomic …

The management of retinoblastoma, the most common intraocular malignancy in children,
has changed drastically over the last decade. Landmark developments in local drug …

Lentiviral vectors have played a critical role in the emergence of gene-modified cell
therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel …

Chimeric antigen receptor (CAR)-engineered T cells can be highly effective in the treatment
of hematological malignancies, but mostly fail in the treatment of solid tumors. Thus …

Allogeneic CD19-specific chimeric antigen receptor (CAR) T cells with inactivated donor T
cell receptor (TCR) expression can be used as an" off-the-shelf" therapeutic modality for …

Cancer is characterized by uncontrolled cell growth, disrupted regulatory pathways, and the
accumulation of genetic mutations. These mutations across different types of cancer lead to …

Chimeric antigen receptor (CAR) T cell immunotherapy involves the genetic modification of
the patient's own T cells so that they specifically recognize and destroy tumour cells …