Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

Abstract Tumour Necrosis Factor α (TNFα), is an inflammatory cytokine produced by
macrophages/monocytes during acute inflammation and is responsible for a diverse range …

The engineering of autologous patient T cells for adoptive cell therapies has revolutionized
the treatment of several types of cancer. However, further improvements are needed to …

Herpes simplex virus (HSV) 1 and 2 infect activated T lymphocytes by attachment of the HSV
envelope glycoprotein D (gD) to the cellular herpesvirus entry mediator (HVEM), an orphan …

Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as
adaptor proteins that couple the tumor necrosis factor receptor family to signaling pathways …

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …

Members of the TNF receptor superfamily play pivotal roles in numerous biological events in
metazoan organisms. Ligand-mediated trimerization by corresponding homo-or …

The signaling pathways that regulate cell survival are beginning to be defined. Receptors
such as Fas and tumor necrosis factor receptor type I (TNFRI) have been shown to be …

The first two members of the tumor necrosis factor receptor-associated factor (TRAF) family
of proteins, TRAF1 and TRAF2, were identified as signal transducers of tumor necrosis factor …

The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of
scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling …