Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene
expression according to parental origin. It has long been established that imprinted genes …

Metabolic health depends on the brain's ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone …

Insulin resistance in muscle and liver and-cell failure represent the core pathophysiologic
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …

Background Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form
of obesity. However, the clinical spectrum and mode of inheritance have not been defined …

Summary Melanocortin-4 receptor (MC4R) mutations cause dysregulation of energy
balance and hyperinsulinemia. We have used mouse models to study the physiological …

Two general approaches to the treatment of type 2 diabetes mellitus (T2DM) have been
advocated. 1) A “guideline” approach that advocates sequential addition of antidiabetes …

Feeding provides substrate for energy metabolism, which is vital to the survival of every
living animal and therefore is subject to intense regulation by brain homeostatic and hedonic …

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated.
Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis …

An insidious increase in features of the'metabolic syndrome'—obesity, insulin resistance and
dyslipidaemia—has conspired to produce a worldwide epidemic of type 2 insulin-resistant …