Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …

Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

Immune responses at the respiratory mucosal interface are critical to prevent respiratory
infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) …

Background Intranasal vaccination may induce protective local and systemic immune
responses against respiratory pathogens. A number of intranasal SARS-CoV-2 vaccine …

Antibodies secreted at the mucosal surface play an integral role in immune defense by
serving to neutralize the pathogen and promote its elimination at the site of entry. Secretory …

Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

The production of immunoglobulin A (IgA) in mammals exceeds all other isotypes, and it is
mostly exported across mucous membranes. The discovery of IgA and the realization that it …

Secretory antibodies of the immunoglobulin A (IgA) class form the first line of antigen‐
specific immune protection against inhaled, ingested, and sexually transmitted pathogens …

Much of the mortality attributed to influenza virus is due to secondary bacterial pneumonia,
particularly from Streptococcus pneumoniae. However, mechanisms underlying this …

The roles of IgG and secretory IgA in the protection of the respiratory tract (RT) against
influenza infection remain unclear. Passive immunization with Ab doses resulting in serum …