Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence

SZ Alshawwa, AA Kassem, RM Farid, SK Mostafa… - Pharmaceutics, 2022 - mdpi.com
There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …

Nanoparticle-based drug delivery system: the magic bullet for the treatment of chronic pulmonary diseases

S Pramanik, S Mohanto, R Manne… - Molecular …, 2021 - ACS Publications
Chronic pulmonary diseases encompass different persistent and lethal diseases, including
chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic …

Cascade‐targeting poly (amino acid) nanoparticles eliminate intracellular bacteria via on‐site antibiotic delivery

W Feng, G Li, X Kang, R Wang, F Liu… - Advanced …, 2022 - Wiley Online Library
Intracellular bacteria in latent or dormant states tolerate high‐dose antibiotics. Fighting
against these opportunistic bacteria has been a long‐standing challenge. Herein, the design …

Nanotechnology‐based targeted drug delivery: an emerging tool to overcome tuberculosis

Z Baranyai, H Soria‐Carrera, M Alleva… - Advanced …, 2021 - Wiley Online Library
The appearance and rapid spread of drug resistant strains of tuberculosis (TB), one of the
deadliest infectious diseases, pose a serious threat to public health and increase the need …

Effect of Nanoparticle Weight on the Cellular Uptake and Drug Delivery Potential of PLGA Nanoparticles

P Kattel, S Sulthana, J Trousil, D Shrestha… - ACS …, 2023 - ACS Publications
Biodegradable and biocompatible polymeric nanoparticles (NPs) stand out as a key tool for
improving drug bioavailability, reducing the inherent toxicity, and targeting the intended site …

Dynamic mucus penetrating microspheres for efficient pulmonary delivery and enhanced efficacy of host defence peptide (HDP) in experimental tuberculosis

A Sharma, K Vaghasiya, P Gupta, AK Singh… - Journal of controlled …, 2020 - Elsevier
Pulmonary drug delivery system is increasingly gaining popularity for several lung diseases
including tuberculosis (TB) due to its ability to attain high drug concentrations at the site of …

Self-Assembly, Drug Encapsulation, and Cellular Uptake of Block and Gradient Copolymers of 2-Methyl-2-oxazine and 2-n-Propyl/butyl-2-oxazoline

D Babuka, K Kolouchova, L Loukotova… - …, 2021 - ACS Publications
Self-assembled amphiphilic polymers have been extensively studied for various biomedical
applications, as they show advantageous properties for diagnosis and therapy. In this work …

Nanotechnology and tuberculosis: An old disease with new treatment strategies

DC dos Santos Macêdo, IDL Cavalcanti, JB de Souza… - Tuberculosis, 2022 - Elsevier
Tuberculosis is an intracellular infectious disease caused by Mycobacterium tuberculosis,
which mainly affects the lungs. Especially in patients infected by the Human …

Dual-targeted poly (amino acid) nanoparticles deliver drug combinations on-site: an intracellular synergistic strategy to eliminate intracellular bacteria

D Zhao, W Feng, X Kang, H Li, F Liu… - Journal of Materials …, 2023 - pubs.rsc.org
Multi-drug combinations are a common strategy for the treatment of intracellular bacterial
infections. However, different internalized pathways and the accumulation of the composite …

A disulfide molecule–vancomycin nanodrug delivery system efficiently eradicates intracellular bacteria

Y Luo, L Su, H Yang, A Geng, S Bai… - Journal of Materials …, 2024 - pubs.rsc.org
Intracellular bacteria often lead to chronic and recurrent infections; however, most of the
known antibiotics have poor efficacy against intracellular bacteria due to their poor cell …