Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

M Iv, N Telischak, D Feng, SJ Holdsworth… - …, 2015 - Taylor & Francis
Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors,
allowing for improved diagnostic and prognostic capabilities. Some challenges persist even …

[HTML][HTML] Microbeam radiation therapy: Clinical perspectives

MA Grotzer, E Schültke, E Bräuer-Krisch, JA Laissue - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT), a novel form of spatially fractionated radiotherapy (RT),
uses arrays of synchrotron-generated X-ray microbeams (MB). MRT has been identified as a …

[HTML][HTML] X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

P Montay-Gruel, A Bouchet, M Jaccard, D Patin… - Radiotherapy and …, 2018 - Elsevier
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our
results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with …

Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model

LML Smyth, JF Donoghue, JA Ventura, J Livingstone… - Scientific reports, 2018 - nature.com
Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam
radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy …

A global analysis of viviparity in squamates highlights its prevalence in cold climates

A Zimin, SV Zimin, R Shine, L Avila… - Global Ecology and …, 2022 - Wiley Online Library
Aim Viviparity has evolved more times in squamates than in any other vertebrate group;
therefore, squamates offer an excellent model system in which to study the patterns, drivers …

Toward personalized synchrotron microbeam radiation therapy

E Engels, N Li, J Davis, J Paino, M Cameron… - Scientific reports, 2020 - nature.com
Synchrotron facilities produce ultra-high dose rate X-rays that can be used for selective
cancer treatment when combined with micron-sized beams. Synchrotron microbeam …

FLASH and minibeams in radiation therapy: the effect of microstructures on time and space and their potential application to protontherapy

A Mazal, Y Prezado, C Ares, L de Marzi… - The British Journal of …, 2020 - academic.oup.com
After years of lethargy, studies on two non-conventional microstructures in time and space of
the beams used in radiation therapy are enjoying a huge revival. The first effect called …

Radiobiological and treatment-related aspects of spatially fractionated radiotherapy

L Moghaddasi, P Reid, E Bezak, LG Marcu - International Journal of …, 2022 - mdpi.com
The continuously evolving field of radiotherapy aims to devise and implement techniques
that allow for greater tumour control and better sparing of critical organs. Investigations into …

Divide and conquer: spatially fractionated radiation therapy

Y Prezado - Expert reviews in molecular medicine, 2022 - cambridge.org
Spatially fractionated radiation therapy (SFRT) challenges some of the classical dogmas in
conventional radiotherapy. The highly modulated spatial dose distributions in SFRT have …

[HTML][HTML] Effects of microbeam radiation therapy on normal and tumoral blood vessels

A Bouchet, R Serduc, JA Laissue, V Djonov - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT) is a new form of preclinical radiotherapy using quasi-
parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred …