Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations)
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …

The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

This review focuses on recent clinical and translational discoveries in severe and
uncontrolled asthma that now enable phenotyping and personalized therapies in these …

Although the term “asthma” has been applied to all patients with airway lability and variable
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …

Cells constantly produce oxidizing species because of their metabolic activity, which is
counteracted by the continuous production of antioxidant species to maintain the …

Objectives To describe the methodological characteristics of mediation analyses (MAs)
reported in recent randomized controlled trials (RCTs) and to propose recommendations on …

Non-type 2 inflammation (Non-T2)-mediated asthma is difficult to define due to lack of
signature biomarkers. It exists in the absence of T2-high or eosinophilic inflammation and …

Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …

Introduction: Due to the uptake in the use of e-cigarettes (ECs), evidence on their health
effects is needed to inform health care and policy. Some regulators and health professionals …

The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …