A journey through the lectin pathway of complement—MBL and beyond
Summary Mannose‐binding lectin (MBL), collectin‐10, collectin‐11, and the ficolins (ficolin‐
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …
A double edged-sword-the complement system during SARS-CoV-2 infection
LE Santiesteban-Lores, TA Amamura, TF da Silva… - Life sciences, 2021 - Elsevier
In the past 20 years, infections caused by coronaviruses SARS-CoV, MERS-CoV and SARS-
CoV-2 have posed a threat to public health since they may cause severe acute respiratory …
CoV-2 have posed a threat to public health since they may cause severe acute respiratory …
[HTML][HTML] Surfactant proteins A and D: trimerized innate immunity proteins with an affinity for viral fusion proteins
Innate recognition of viruses is an essential part of the immune response to viral pathogens.
This is integral to the maintenance of healthy lungs, which are free from infection and …
This is integral to the maintenance of healthy lungs, which are free from infection and …
Complement-mediated neutralisation identified in Ebola virus disease survivor plasma: implications for protection and pathogenesis
J Mellors, T Tipton, SK Fehling, J Akoi Bore… - Frontiers in …, 2022 - frontiersin.org
The 2013–2016 Ebola virus (EBOV) epidemic in West Africa was unprecedented in case
numbers and fatalities, and sporadic outbreaks continue to arise. Antibodies to the EBOV …
numbers and fatalities, and sporadic outbreaks continue to arise. Antibodies to the EBOV …
Ficolins and the recognition of pathogenic microorganisms: an overview of the innate immune response and contribution of single nucleotide polymorphisms
Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the
innate immune response to numerous pathogens throughout the circulation, as well as …
innate immune response to numerous pathogens throughout the circulation, as well as …
Mechanisms of filovirus entry
RA Davey, O Shtanko, M Anantpadma… - … -and Ebolaviruses: From …, 2017 - Springer
Filovirus entry into cells is complex, perhaps as complex as any viral entry mechanism
identified to date. However, over the past 10 years, the important events required for …
identified to date. However, over the past 10 years, the important events required for …
Complement proteins as soluble pattern recognition receptors for pathogenic viruses
The complement system represents a crucial part of innate immunity. It contains a diverse
range of soluble activators, membrane-bound receptors, and regulators. Its principal function …
range of soluble activators, membrane-bound receptors, and regulators. Its principal function …
Achieving cross-reactivity with pan-ebolavirus antibodies
Highlights•Several structures are now available of broadly reactive antibodies in complex
with GP.•Many broadly reactive antibodies bind along the 'waist'of GP in three primary …
with GP.•Many broadly reactive antibodies bind along the 'waist'of GP in three primary …
The structural basis for filovirus neutralization by monoclonal antibodies
Highlights•Filovirus neutralization and protection is related to epitope on filovirus GPs.•GP
epitopes on marburgvirus and ebolavirus differ fundamentally at a structural …
epitopes on marburgvirus and ebolavirus differ fundamentally at a structural …
Macrophage infection, activation, and histopathological findings in ebolavirus infection
TG Wanninger, DE Millian, OA Saldarriaga… - Frontiers in Cellular …, 2022 - frontiersin.org
Macrophages contribute to Ebola virus disease through their susceptibility to direct infection,
their multi-faceted response to ebolaviruses, and their association with pathological findings …
their multi-faceted response to ebolaviruses, and their association with pathological findings …