Motivated by the conceptual framework of multi-scale biomechanics, this narrative review
highlights recent major advances with a focus on gait and joint kinematics, then tissue-level …

Inappropriate biomechanics, namely wear-and-tear, has been long believed to be a main
cause of osteoarthritis (OA). However, this view is now being re-evaluated, especially when …

The drive to develop cartilage implants for the treatment of major defects in the
musculoskeletal system has resulted in a major research thrust towards developing …

Osteoarthritis (OA), a degenerative joint disease, is the most common chronic condition of
the joints, which cannot be prevented effectively. Computational modeling of joint …

Musculoskeletal tissues respond to optimal mechanical signals (eg, strains) through
anabolic adaptations, while mechanical signals above and below optimal levels cause …

Atomic force microscopy (AFM) has become a powerful tool for the characterization of
materials at the nanoscale. Nevertheless, its application to hierarchical biological tissue like …

The heterogeneous, nonlinear, anisotropic material behavior of biological tissues makes
precise definition of an accurate constitutive model difficult. One possible solution to this …

Osteoarthritis (OA) has a complex, heterogeneous and only partly understood etiology.
There is a definite role of joint cartilage pathomechanics in originating and progressing of …

Hyaline cartilage undergoes many substantial age-related physiochemical and
biomechanical changes that reduce its ability to overcome the effects of mechanical stress …

The facet capsular ligaments encapsulate the bilateral spinal facet joints and are common
sources of painful injury due to afferent innervation. These ligaments exhibit architectural …