Despite the discovery of modified nucleic acids nearly 75 years ago, their biological
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …

Protein–RNA complexes exist in many forms within the cell, from stable machines such as
the ribosome to transient assemblies like the spliceosome. All protein–RNA assemblies rely …

Multiple mechanisms are involved in kidney damage, among which the role of epigenetic
modifications in the occurrence and development of kidney diseases is constantly being …

Dear Editor, N6-methyladenosine (m6A) is a prevalent epigenetic modification found in
eukaryotic mRNA and plays a crucial role in regulating gene expression in various …

Shiga toxin (Stx) released by Shiga toxin producing Escherichia coli (STEC) causes life-
threatening illness. Its production and release require induction of Stx-encoding prophage …

Cellular senescence is a state of irreversible cellular growth arrest that occurs in response to
various stresses. In addition to exiting the cell cycle, senescent cells undergo many …

PCIF1 and FTO are a pair of human mRNA cap-specific modification enzymes that have
opposing activities. PCIF1 adds a methyl group to the N6-position of 2′ O-methyladenosine …

Much is known about the generation, removal, and roles of 5-methylcytosine (5mC) in
eukaryote DNA, and there is a growing body of evidence regarding N6-methyladenine, but …

The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme
that deposits N 6-methyladenosine (m 6 A) modifications on messenger RNA (mRNA) in …

The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified
cytosine—5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5 …