Identification of neoantigens for individualized therapeutic cancer vaccines
Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …
recognized by autologous T cells in the host. As neoepitopes are not subject to central …
Artificial intelligence in molecular medicine
Artificial Intelligence in Molecular Medicine | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …
content The New England Journal of Medicine homepage Advanced Search SEARCH …
Towards generalist biomedical AI
Background Medicine is inherently multimodal, requiring the simultaneous interpretation
and integration of insights between many data modalities spanning text, imaging, genomics …
and integration of insights between many data modalities spanning text, imaging, genomics …
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
Z Yang, C Yan, J Ma, P Peng, X Ren, S Cai, X Shen… - Nature …, 2023 - nature.com
Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE …
LJ Padrón, DM Maurer, MH O'Hara, EM O'Reilly… - Nature medicine, 2022 - nature.com
Chemotherapy combined with immunotherapy has improved the treatment of certain solid
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma …
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma …
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
Multi-omic machine learning predictor of breast cancer therapy response
Breast cancers are complex ecosystems of malignant cells and the tumour
microenvironment. The composition of these tumour ecosystems and interactions within …
microenvironment. The composition of these tumour ecosystems and interactions within …
Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with
checkpoint inhibitors is still not very clear. We utilize single-cell RNA-and ATAC-sequencing …
checkpoint inhibitors is still not very clear. We utilize single-cell RNA-and ATAC-sequencing …
Emergence of methicillin resistance predates the clinical use of antibiotics
The discovery of antibiotics more than 80 years ago has led to considerable improvements
in human and animal health. Although antibiotic resistance in environmental bacteria is …
in human and animal health. Although antibiotic resistance in environmental bacteria is …
An intronic GAA repeat expansion in FGF14 causes the autosomal-dominant adult-onset ataxia SCA27B/ATX-FGF14
Adult-onset cerebellar ataxias are a group of neurodegenerative conditions that challenge
both genetic discovery and molecular diagnosis. In this study, we identified an intronic (GAA) …
both genetic discovery and molecular diagnosis. In this study, we identified an intronic (GAA) …