Key Points Frailty in Older Adults Assessing frailty enables clinicians to predict the outcomes
and risks of health conditions, target the delivery of evidence-based interventions, and tailor …

Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be
defined as exercise-induced decrease in the ability to produce force. Here, to provide a …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

Importance Mitochondrial dysfunction is a core component of the aging process and may
play a key role in atherosclerotic cardiovascular disease. Mitochondrial DNA copy number …

Frailty is common and associated with poorer outcomes in the elderly, but its role as
potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …