The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Tumor microenvironment in ovarian cancer: function and therapeutic strategy

Y Yang, Y Yang, J Yang, X Zhao, X Wei - Frontiers in cell and …, 2020 - frontiersin.org
Ovarian cancer is one of the leading causes of death in patients with gynecological
malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy …

Reactive oxygen species: a volatile driver of field cancerization and metastasis

Z Liao, D Chua, NS Tan - Molecular cancer, 2019 - Springer
Field cancerization and metastasis are the leading causes for cancer recurrence and
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …

[HTML][HTML] HDAC inhibitors: Targets for tumor therapy, immune modulation and lung diseases

G Shanmugam, S Rakshit, K Sarkar - Translational Oncology, 2022 - Elsevier
Histone deacetylases (HDACs) are enzymes that play a key role in the epigenetic regulation
of gene expression by remodeling chromatin. Inhibition of HDACs is a prospective …

[HTML][HTML] Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

X Liu, GD Hogg, C Zuo, NC Borcherding, JM Baer… - Cancer Cell, 2023 - cell.com
Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of
immunosuppressive tumors. Previous studies have shown that CD11b integrin agonists …

Recent advances in MOF-based nanoplatforms generating reactive species for chemodynamic therapy

Y Zhong, X Li, J Chen, X Wang, L Wei, L Fang… - Dalton …, 2020 - pubs.rsc.org
Still today, cancer remains a threat to human health. Possible common treatments to cure
this disease include chemotherapy (CT), radiotherapy (RT), photothermal therapy (PTT), and …

[HTML][HTML] A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: functional validation and clinical significance

Q Meng, C Liang, J Hua, B Zhang, J Liu, Y Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Dysregulated microRNA (miRNA) expression in cancer can act as a key factor
that modifies biological processes, including chemoresistance. Our study aimed to identify …

Wnt/β-catenin signaling: the culprit in pancreatic carcinogenesis and therapeutic resistance

M Ram Makena, H Gatla, D Verlekar… - International journal of …, 2019 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths.
Even though there is a steady increase in patient survival for most cancers over the …

Opportunities, barriers, and a strategy for overcoming translational challenges to therapeutic nucleic acid nanotechnology

KA Afonin, MA Dobrovolskaia, G Church… - Therapeutic RNA …, 2021 - taylorfrancis.com
606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …

Therapeutic influence on important targets associated with chronic inflammation and oxidative stress in cancer treatment

M Neganova, J Liu, Y Aleksandrova, S Klochkov, R Fan - Cancers, 2021 - mdpi.com
Simple Summary There is no doubt that the need for new effective methods of cancer
treatment remains challenging, as cancer is the second cause of death based on the …