The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives
S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …
correspondence between disease mortality and incidence. Furthermore, it is usually …
Tumor microenvironment in ovarian cancer: function and therapeutic strategy
Y Yang, Y Yang, J Yang, X Zhao, X Wei - Frontiers in cell and …, 2020 - frontiersin.org
Ovarian cancer is one of the leading causes of death in patients with gynecological
malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy …
malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy …
Reactive oxygen species: a volatile driver of field cancerization and metastasis
Field cancerization and metastasis are the leading causes for cancer recurrence and
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …
[HTML][HTML] HDAC inhibitors: Targets for tumor therapy, immune modulation and lung diseases
Histone deacetylases (HDACs) are enzymes that play a key role in the epigenetic regulation
of gene expression by remodeling chromatin. Inhibition of HDACs is a prospective …
of gene expression by remodeling chromatin. Inhibition of HDACs is a prospective …
[HTML][HTML] Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of
immunosuppressive tumors. Previous studies have shown that CD11b integrin agonists …
immunosuppressive tumors. Previous studies have shown that CD11b integrin agonists …
Recent advances in MOF-based nanoplatforms generating reactive species for chemodynamic therapy
Y Zhong, X Li, J Chen, X Wang, L Wei, L Fang… - Dalton …, 2020 - pubs.rsc.org
Still today, cancer remains a threat to human health. Possible common treatments to cure
this disease include chemotherapy (CT), radiotherapy (RT), photothermal therapy (PTT), and …
this disease include chemotherapy (CT), radiotherapy (RT), photothermal therapy (PTT), and …
[HTML][HTML] A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: functional validation and clinical significance
Q Meng, C Liang, J Hua, B Zhang, J Liu, Y Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Dysregulated microRNA (miRNA) expression in cancer can act as a key factor
that modifies biological processes, including chemoresistance. Our study aimed to identify …
that modifies biological processes, including chemoresistance. Our study aimed to identify …
Wnt/β-catenin signaling: the culprit in pancreatic carcinogenesis and therapeutic resistance
Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths.
Even though there is a steady increase in patient survival for most cancers over the …
Even though there is a steady increase in patient survival for most cancers over the …
Opportunities, barriers, and a strategy for overcoming translational challenges to therapeutic nucleic acid nanotechnology
606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
Therapeutic influence on important targets associated with chronic inflammation and oxidative stress in cancer treatment
M Neganova, J Liu, Y Aleksandrova, S Klochkov, R Fan - Cancers, 2021 - mdpi.com
Simple Summary There is no doubt that the need for new effective methods of cancer
treatment remains challenging, as cancer is the second cause of death based on the …
treatment remains challenging, as cancer is the second cause of death based on the …