Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

Abstract Cytochrome P450 3A4 (CYP3A4) metabolizes∼ 50% of all clinically used drugs.
Although CYP3A4 expression varies widely between individuals, the contribution of genetic …

Rivaroxaban is an anticoagulant drug that prevents forming of blood clots. In addition, it can
be administered to prevent and treat thrombotic diseases such as atrial fibrillation, cardiac …

The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …

CYP3A4 is the most important drug metabolizing enzyme in adult humans because of its
prominent expression in liver and gut and because of its broad substrate specificity, which …

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced
enzyme function. We aimed to evaluate the influence of these alleles on the …

Background Sunitinib is a tyrosine kinase inhibitor with proven efficacy in renal-cell
carcinoma, but some patients do not respond or need dose reductions due to toxicity …

The polymorphic P450 (CYP) enzyme superfamily is the most important system involved in
the biotransformation of many endogenous and exogenous substances including drugs …

Background and Objective The in vivo implication of various cytochrome P450 (CYP)
isoforms and of P‐glycoprotein on methadone kinetics is unclear. We aimed to thoroughly …