Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Stem-cell-derived epithelial organoids are routinely used for the biological and biomedical
modelling of tissues. However, the complexity, lack of standardization and quality control of …

Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

Organs are complex systems composed of different cells, proteins and signalling molecules
that are arranged in a highly ordered structure to orchestrate a myriad of functions in our …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable
modeling of human physiology and disease. The technology has emerged from converging …

There is growing appreciation of the role that the extracellular environment plays in
regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in …

The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Although only a few stem cell-based therapies are currently available to patients, stem cells
hold tremendous regenerative potential, and several exciting clinical applications are on the …