De novo organ regeneration has been observed in several lower organisms, as well as
rodents; however, demonstrating these regenerative properties in human cells and tissues …

Information processing and storage underpins many biological processes of vital importance
to organism survival. Like animals, plants also acquire, store and process environmental …

Stem cell models for early mammalian development offer new experimental opportunities to
access spatio-temporal details of the cell-cell interactions that govern cell differentiation and …

Wnt signaling is required to maintain bipotent progenitors for neural and paraxial mesoderm
cells, the neuromesodermal progenitor (NMP) cells that reside in the epiblast and tailbud …

Paracrine signals maintain developmental states and create cell fate patterns in vivo and
influence differentiation outcomes in human embryonic stem cells (hESCs) in vitro …

Microbes are intensely social organisms that routinely cooperate and coordinate their
activities to express elaborate population level phenotypes. Such coordination requires a …

Background A wide range of bacteria species are known to communicate through the so
called quorum sensing (QS) mechanism by means of which they produce a small molecule …

The mesodermal precursor populations for different internal organ systems are specified
during gastrulation by the combined activity of extracellular signaling systems such as BMP …

Wnt signalling is a key regulator of vertebrate heart development, yet it is unclear which
specific Wnt signalling components are required to regulate which aspect of cardiogenesis …

Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a
formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have …