Introduction: Aminoglycosides have been long used for antibacterial treatment and are still
commonly used in clinical practice. Despite their extensive application and positive effects …

The toxicity of aminoglycosides including gentamicin (GEN), the most widely used drug in
this category, is believed to be related to the generation of reactive oxygen species (ROS) in …

Nephrotoxicity limits the use of aminoglycoside antibiotics. Kidney damage is produced
mainly in the renal tubule due to an inflammatory and oxidative process. At preclinical level …

Background Nitric oxide is a mediator of potential importance in numerous physiological and
inflammatory processes in the lung. Aminoguanidine (AG) has been shown to have anti …

Background and Aims Despite its beneficial effects, cisplatin has considerable nephrotoxic,
ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive …

The micro-and macro-complications in diabetes mellitus (DM) mainly arise from the damage
induced by Amadori and advanced glycation end products, as well as the released free …

Reactive oxygen species and cytokines have been implicated in the nephrotoxicity induced
by doxorubicin. The goal of the present study was to determine protective effect of …

Random flaps in DM patients have poor reliability for wound coverage, and flap loss remains
a complex challenge. The protective effects of aminoguanidine (AG) administration on the …

Amikacin (AK) is an aminoglycoside that is widely used to treat life-threatening Gram-
negative infections, especially in intensive care units. Despite its wide clinical indications …

This experimental study was designed to investigate both protective and therapeutic effects
of aminoguanidine (AG), on radiotherapy (RT)‐induced oxidative stress in kidney and testis …