[HTML][HTML] Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2

N Cheng, KH Kim, LF Lau - JCI insight, 2022 - ncbi.nlm.nih.gov
Senescent cells have long been associated with deleterious effects in aging-related
pathologies, although recent studies have uncovered their beneficial roles in certain …

Cellular communication network factor 1‐stimulated liver macrophage efferocytosis drives hepatic stellate cell activation and liver fibrosis

KH Kim, N Cheng, LF Lau - Hepatology Communications, 2022 - journals.lww.com
Following inflammatory injury in the liver, neutrophils quickly infiltrate the injured tissue to
defend against microbes and initiate the repair process; these neutrophils are short lived …

CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation

BA Imhof, S Jemelin, R Ballet, C Vesin… - Proceedings of the …, 2016 - National Acad Sciences
Inflammation is characterized by the recruitment of leukocytes from the bloodstream. The
rapid arrival of neutrophils is followed by a wave of inflammatory lymphocyte antigen 6 …

CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling

JI Jun, LF Lau - Nature communications, 2020 - nature.com
Expression of the matricellular protein CCN1 (CYR61) is associated with inflammation and
is required for successful wound repair. Here, we show that CCN1 binds bacterial pathogen …

Toll‐like receptors elicit different recruitment kinetics of monocytes and neutrophils in mouse acute inflammation

BA Imhof, S Jemelin, Y Emre - European journal of immunology, 2017 - Wiley Online Library
Leukocyte recruitment is an important process in combating pathogens. The largest class of
circulating leukocytes are neutrophils, which rapidly invade inflamed tissue, followed by …

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

B Feng, G Xu, K Sun, K Duan, B Shi… - Cardiovascular …, 2020 - Springer
Background The prevalence of peripheral artery disease (PAD) is obviously increased in
patients with diabetes. Existing evidence shows that cysteine-rich angiogenic inducer 61 …

Evaluation of serum cysteine-rich protein 61 levels in patients with coronary artery disease

J Deng, X Qian, J Li, Y Li, Y Li, Y Luo - Biomarkers in Medicine, 2018 - Taylor & Francis
Aim: The aim is to evaluate serum cysteine-rich protein 61 (Cyr61) levels in patients with
coronary artery disease (CAD). Patients & methods: Serum Cyr61 levels were measured in …

Regulation of CCN1 (Cyr61) in a porcine model of intestinal ischemia/reperfusion

H Shegarfi, CD Krohn, Y Gundersen… - Innate …, 2015 - journals.sagepub.com
Intestinal ischemia is a serious condition that may lead to both local and systemic
inflammatory responses. Restoration of blood supply (reperfusion) to ischemic tissues often …

Analysis of CCN Functions in Liver Regeneration After Partial Hepatectomy

N Cheng, KH Kim, LF Lau - CCN Proteins: Methods and Protocols, 2022 - Springer
The remarkable regenerative capability of the liver has long been appreciated. Upon
significant loss of liver tissue, the remnant liver can grow rapidly to restore the original liver …

Senescent Cells Promote Liver Regeneration Through IL-6 and Ligands of CXCR2

N Cheng - 2022 - search.proquest.com
Senescent cells have long been associated with deleterious effects in aging-related
pathologies, although more recent studies have uncovered their beneficial roles in certain …