Hydroxyurea has many characteristics of an ideal drug for sickle cell anemia (SCA) and
provides therapeutic benefit through multiple mechanisms of action. Over the past 25 years …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Context Sickle cell anemia (SCA) is a chronic illness causing progressive deterioration in
quality of life. Brain dysfunction may be the most important and least studied problem …

Sickle cell disease (SCD) is a group of inherited autosomal recessive disorders, including
sickle cell anemia, sickle beta-thalassemia, and other hemoglobinopathies, which are …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Neurocognitive impairment is common in sickle cell disease (SCD) and is associated with
significant functional limitations. In a cross‐sectional analysis, we examined the association …

Case 2: A 5-year-old girl with HbSS is being seen for a routine follow-up visit. She has never
had acute chest syndrome or other sickle cell–related complications. She currently has …

Aim Sickle cell disease (SCD) is the commonest cause of childhood stroke worldwide.
Magnetic resonance imaging (MRI) is routinely used to detect additional silent cerebral …

Individuals with sickle cell disease (SCD) experience cognitive deficits; however, it remains
unclear whether medical treatments for SCD improve cognition. Given that executive …

Sickle cell disease is now a chronic adult illness characterized by progressive multiorgan
failure, particularly involving the brain and kidney. The etiology is multifactorial; it includes …