Current drug therapy and pharmaceutical challenges for Chagas disease

J Bermudez, C Davies, A Simonazzi, JP Real, S Palma - Acta tropica, 2016 - Elsevier
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

[HTML][HTML] Chagas disease in the 21st century: a public health success or an emerging threat?

KM Bonney - Parasite, 2014 - ncbi.nlm.nih.gov
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major public
health burden in Latin America and a potentially serious emerging threat to a number of …

[HTML][HTML] CD8+ T cells in Trypanosoma cruzi infection

RL Tarleton - Seminars in immunopathology, 2015 - Springer
Trypanosoma cruzi infection and Chagas disease remains among the most neglected of the
neglected tropical diseases. Despite this, studies of the immune response to T. cruzi have …

Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease

N Cortes-Serra, M Gualdron-Lopez… - Journal of …, 2022 - Wiley Online Library
Chagas disease, caused by the protozoa parasite Trypanosoma cruzi, is a neglected
tropical disease and a major public health problem affecting more than 6 million people …

[HTML][HTML] A Review on the Immunological Response against Trypanosoma cruzi

G Macaluso, F Grippi, S Di Bella, V Blanda, F Gucciardi… - Pathogens, 2023 - mdpi.com
Chagas disease is a chronic systemic infection transmitted by Trypanosoma cruzi. Its life
cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi …

[HTML][HTML] Immunity and vaccine development efforts against Trypanosoma cruzi

LE Rios, JC Vázquez-Chagoyán, AO Pacheco… - Acta tropica, 2019 - Elsevier
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …

Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

E Dumonteil, ME Bottazzi, B Zhan… - Expert review of …, 2012 - Taylor & Francis
Chagas disease is a leading cause of heart disease affecting approximately 10 million
people in Latin America and elsewhere worldwide. The two major drugs available for the …

Chagas disease (American trypanosomiasis) in Mexico: an update

A Carabarin-Lima, MC González-Vázquez… - Acta tropica, 2013 - Elsevier
Chagas disease is a parasitic infection caused by the protozoan Trypanosoma cruzi, a
flagellated organism that is transmitted mainly to humans through the infected feces of …

Developments in the management of Chagas cardiomyopathy

HB Tanowitz, FS Machado, DC Spray… - Expert review of …, 2015 - Taylor & Francis
Over 100 years have elapsed since the discovery of Chagas disease and there is still much
to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs …

Nanomedicines against Chagas disease: an update on therapeutics, prophylaxis and diagnosis

MJ Morilla, EL Romero - Nanomedicine, 2015 - Taylor & Francis
Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma
cruzi. After a mostly clinically silent acute phase, the disease becomes a lifelong chronic …