Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …

Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …

Translation is pervasive outside of canonical coding regions, occurring in long noncoding
RNAs, canonical untranslated regions and introns,,–, especially in ageing …

The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular
compartments, within which they are further organized into protein complexes. The …

Molecular chaperones of the Hsp70 family form an important hub in the cellular protein
folding networks in bacteria and eukaryotes, connecting translation with the downstream …

The formation of membraneless organelles can be a proteotoxic stress control mechanism
that locally condenses a set of components capable of mediating protein degradation …

Like all eukaryotic organisms, plants possess an innate program for controlled cellular
demise termed programmed cell death (PCD). Despite the functional conservation of PCD …

Newly synthesized proteins are triaged between biosynthesis and degradation to maintain
cellular homeostasis, but the decision-making mechanisms are unclear. We reconstituted …

One-fourth of eukaryotic genes code for integral membrane proteins, nearly all of which are
inserted and assembled at the endoplasmic reticulum (ER). The defining feature of …