How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Embryonic cells grow in environments that provide a plethora of physical cues, including
mechanical forces that shape the development of the entire embryo. Despite their …

The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs,
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at
the earliest stages of development. Our understanding of ECM composition, structure and …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

Neural-tube closure is a critical step of embryogenesis, and its failure causes serious birth
defects. Coordination of two morphogenetic processes—convergent extension and neural …