In 1917, a food chemist named James Currie made a promising discovery: any strain of the
filamentous mould Aspergillus niger would produce high concentrations of citric acid when …

Aspergillus niger has become one of the most important hosts for food enzyme production
due to its unique food safety characteristics and excellent protein secretion systems. A series …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

Aspergillus niger was engineered using a gene responsible for citric acid transport, which
has a significant impact on citric acid secretion when overexpressed. The transport gene …

Filamentous fungi are harnessed as cell factories for the production of a diverse range of
organic acids, proteins, and secondary metabolites. Growth and morphology have critical …

As a powerful tool for fast and precise genome editing, the CRISPR/Cas9 system has been
applied in filamentous fungi to improve the efficiency of genome alteration. However, the …

Filamentous fungi produce a vast number of bioactive secondary metabolites (SMs), some of
which have found applications in the pharmaceutical industry including as antibiotics and …

Aspergilli have a long history in biotechnology as expression platforms for the production of
food ingredients, pharmaceuticals and enzymes. The achievements made during the last …

Metabolic engineering requires functional genetic tools for easy and quick generation of
multiple pathway variants. A genetic engineering toolbox for A. niger is presented, which …