Cell death mediated by the pyroptosis pathway with the aid of nanotechnology: prospects for cancer therapy

D Wu, S Wang, G Yu, X Chen - Angewandte Chemie, 2021 - Wiley Online Library
Pyroptosis, a unique form of programmed cell death (PCD) that is characterized by DNA
fragmentation, chromatin condensation, cellular swelling with big bubbles, and leakage of …

Understanding nanomaterial–liver interactions to facilitate the development of safer nanoapplications

J Li, C Chen, T Xia - Advanced Materials, 2022 - Wiley Online Library
Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

[HTML][HTML] A pyroptosis nanotuner for cancer therapy

B Chen, Y Yan, Y Yang, G Cao, X Wang… - Nature …, 2022 - nature.com
Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane
perforation and that can be exploited for biomedical applications in cancer therapy …

The nano–bio interactions of nanomedicines: understanding the biochemical driving forces and redox reactions

Y Wang, R Cai, C Chen - Accounts of chemical research, 2019 - ACS Publications
Conspectus Engineered nanomaterials (ENMs) have been developed for imaging, drug
delivery, diagnosis, and clinical therapeutic purposes because of their outstanding …

Emerging pyroptosis-engineered nanobiotechnologies regulate cancers and inflammatory diseases: A double-edged sword

Y Zhang, C Fang, W Zhang, K Zhang - Matter, 2022 - cell.com
Pyroptosis is closely associated with tumors and inflammatory diseases. By enhancing
pyroptosis, direct and immune-response-triggered deaths of tumor cells are increased …

Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications

H Zheng, J Jiang, S Xu, W Liu, Q Xie, X Cai, J Zhang… - Nanoscale, 2021 - pubs.rsc.org
Although ferroptosis is an iron-dependent cell death mechanism involved in the
development of some severe diseases (eg, Parkinsonian syndrome, stroke and tumours) …

Nanomedicine‐enabled/augmented cell pyroptosis for efficient tumor nanotherapy

Z Zhang, Y Zhou, S Zhao, L Ding, B Chen… - Advanced …, 2022 - Wiley Online Library
The terrible morbidity and mortality of malignant tumors urgently require innovative
therapeutics, especially for apoptosis‐resistant tumors. Pyroptosis, a pro‐inflammatory form …

Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation

Q Chi, T Xu, Y He, Z Li, X Tang, X Fan, S Li - Journal of Hazardous Materials, 2022 - Elsevier
The widespread use of plastics and the rapid development of nanotechnology bring
convenience to our lives while also increasing the environmental burden and increasing the …

[HTML][HTML] Toxicity of manufactured nanomaterials

Y Liu, S Zhu, Z Gu, C Chen, Y Zhao - Particuology, 2022 - Elsevier
Manufactured nanomaterials with unique properties have been extensively applied in
various industrial, agricultural or medical fields. However, some of the properties have been …

Nanoceria, the versatile nanoparticles: Promising biomedical applications

MA Saifi, S Seal, C Godugu - Journal of Controlled Release, 2021 - Elsevier
Nanotechnology has been a boon for the biomedical field due to the freedom it provides for
tailoring of pharmacokinetic properties of different drug molecules. Nanomedicine is the …