[HTML][HTML] Cognitive reserve in model systems for mechanistic discovery: The importance of longitudinal studies
The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …
models, directed at understanding and modifying the relationship between cognition and …
New frontiers in translational research: Touchscreens, open science, and the mouse translational research accelerator platform
Many neurodegenerative and neuropsychiatric diseases and other brain disorders are
accompanied by impairments in high‐level cognitive functions including memory, attention …
accompanied by impairments in high‐level cognitive functions including memory, attention …
[HTML][HTML] The continuous performance test (rCPT) for mice: a novel operant touchscreen test of attentional function
CH Kim, M Hvoslef-Eide, SRO Nilsson… - …, 2015 - Springer
Abstract Rationale Continuous performance tests (CPTs) are widely used to assess
attentional processes in a variety of disorders including Alzheimer's disease and …
attentional processes in a variety of disorders including Alzheimer's disease and …
Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan–McDermid syndrome and autism
SHANK3 is a synaptic scaffolding protein localized in the postsynaptic density and has a
crucial role in synaptogenesis and neural physiology. Deletions and point mutations in …
crucial role in synaptogenesis and neural physiology. Deletions and point mutations in …
The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia
Abstract Rationale The NEWMEDS initiative (Novel Methods leading to New Medications in
Depression and Schizophrenia, http://www. newmeds-europe. com) is a large industrial …
Depression and Schizophrenia, http://www. newmeds-europe. com) is a large industrial …
Cognitive endophenotypes, gene–environment interactions and experience-dependent plasticity in animal models of schizophrenia
EL Burrows, AJ Hannan - Biological psychology, 2016 - Elsevier
Schizophrenia is a devastating brain disorder caused by a complex and heterogeneous
combination of genetic and environmental factors. In order to develop effective new …
combination of genetic and environmental factors. In order to develop effective new …
Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice
Cognitive flexibility has traditionally been considered a frontal lobe function. However,
converging evidence suggests involvement of a larger brain circuit which includes the …
converging evidence suggests involvement of a larger brain circuit which includes the …
Translational assays for assessment of cognition in rodent models of Alzheimer's disease and dementia
Cognitive dysfunction appears as a core feature of dementia, which includes its most
prevalent form, Alzheimer's disease (AD), as well as vascular dementia, frontotemporal …
prevalent form, Alzheimer's disease (AD), as well as vascular dementia, frontotemporal …
[HTML][HTML] Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference
Cognitive dysfunction including disrupted behavioral flexibility is central to
neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). A cognitive …
neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). A cognitive …
Reversal learning and experimenter-administered chronic intermittent ethanol exposure in male rats
KA Badanich, ME Fakih, TS Gurina, EK Roy… - …, 2016 - Springer
Rationale Chronic alcohol exposure is associated with impaired decision making skills,
cognitive deficits, and poor performance on tasks requiring behavioral flexibility. Although …
cognitive deficits, and poor performance on tasks requiring behavioral flexibility. Although …