Epigenetic regulators of the revascularization response to chronic arterial occlusion
Peripheral arterial disease (PAD) is the leading cause of lower limb amputation and
estimated to affect over 202 million people worldwide. PAD is caused by atherosclerotic …
estimated to affect over 202 million people worldwide. PAD is caused by atherosclerotic …
Targeting Anti-Angiogenic VEGF165b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease …
Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A
over-expression nor L-Arginine (NO-precursor) supplementation has been effective in …
over-expression nor L-Arginine (NO-precursor) supplementation has been effective in …
MicroRNA-30b is both necessary and sufficient for interleukin-21 receptor-mediated angiogenesis in experimental peripheral arterial disease
The interleukin-21 receptor (IL-21R) can be upregulated in endothelial cells (EC) from
ischemic muscles in mice following hind-limb ischemia (HLI), an experimental peripheral …
ischemic muscles in mice following hind-limb ischemia (HLI), an experimental peripheral …
Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia
Objective—Surgical hindlimb ischemia (HLI) in mice has become a valuable preclinical
model to study peripheral arterial disease. We previously identified that the different …
model to study peripheral arterial disease. We previously identified that the different …
Exposure of endothelium to biomimetic flow waveforms yields identification of miR-199a-5p as a potent regulator of arteriogenesis
Arteriogenesis, the growth of endogenous collateral arteries bypassing arterial occlusion (s),
is a fundamental shear stress-induced adaptation with implications for treating peripheral …
is a fundamental shear stress-induced adaptation with implications for treating peripheral …
The roles of interleukins in perfusion recovery after peripheral arterial disease
L Chen, H Liu, M Yuan, W Lu, J Wang… - Bioscience …, 2018 - portlandpress.com
In peripheral arterial disease (PAD) patients, occlusions in the major arteries that supply the
leg makes blood flow dependent on the capacity of neovascularization. There is no current …
leg makes blood flow dependent on the capacity of neovascularization. There is no current …
Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle
NJM Nasir, H Heemskerk, J Jenkins, NH Hamadee… - Elife, 2023 - elifesciences.org
The reasons for poor healing of pressure injuries are poorly understood. Vascular ulcers are
worsened by extracellular release of hemoglobin, so we examined the impact of myoglobin …
worsened by extracellular release of hemoglobin, so we examined the impact of myoglobin …
Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia
L Beltran-Camacho, M Jimenez-Palomares… - Stem Cell Research & …, 2020 - Springer
Background Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral
arterial occlusive disease, characterized by the blockade of arteries supplying blood to the …
arterial occlusive disease, characterized by the blockade of arteries supplying blood to the …
MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis
JL Heuslein, SP McDonnell, J Song… - … in Bioengineering and …, 2018 - frontiersin.org
The growth of endogenous collateral arteries that bypass arterial occlusion (s), or
arteriogenesis, is a fundamental shear stress-induced adaptation with implications for …
arteriogenesis, is a fundamental shear stress-induced adaptation with implications for …
Computational network model prediction of hemodynamic alterations due to arteriolar rarefaction and estimation of skeletal muscle perfusion in peripheral arterial …
Objective To estimate the relative influence of input pressure and arteriole rarefaction on
gastrocnemius muscle perfusion in patients with PAD after exercise and/or percutaneous …
gastrocnemius muscle perfusion in patients with PAD after exercise and/or percutaneous …