The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …

The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for
obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate …

Fasting is part of many weight management and health-boosting regimens. Fasting causes
substantial metabolic adaptations in the liver that include the stimulation of fatty acid …

The cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H
(CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily …

An elaborate metabolic response to fasting is orchestrated by the liver and is heavily reliant
on transcriptional regulation. In response to hormones (glucagon, glucocorticoids) many …

Abstract Fibroblast growth factor 21 (Fgf21) is a liver‐derived, fasting‐induced hormone with
broad effects on growth, nutrient metabolism, and insulin sensitivity. Here, we report the …

Peroxisome proliferator-activated receptor α (PPARα) is a therapeutic target for
hyperlipidemia. Pemafibrate (K-877) is a new selective PPARα modulator activating PPARα …

Objective Dietary medium-chain fatty acids (MCFAs), characterized by chain lengths of 8–12
carbon atoms, have been proposed to have beneficial effects on glucose and lipid …

The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis
and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription …

Brown adipose tissue (BAT) is an attractive therapeutic target for treating obesity and
metabolic diseases. Octacosanol is the main component of policosanol, a mixture of very …