Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Lyotropic liquid crystal engineering moving beyond binary compositional space–ordered nanostructured amphiphile self-assembly materials by design
Ordered amphiphile self-assembly materials with a tunable three-dimensional (3D)
nanostructure are of fundamental interest, and crucial for progressing several biological and …
nanostructure are of fundamental interest, and crucial for progressing several biological and …
Martini 3: a general purpose force field for coarse-grained molecular dynamics
The coarse-grained Martini force field is widely used in biomolecular simulations. Here we
present the refined model, Martini 3 (http://cgmartini. nl), with an improved interaction …
present the refined model, Martini 3 (http://cgmartini. nl), with an improved interaction …
Architecture of the human erythrocyte ankyrin-1 complex
The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex,
but how it tethers the spectrin–actin cytoskeleton to the lipid bilayer and the nature of its …
but how it tethers the spectrin–actin cytoskeleton to the lipid bilayer and the nature of its …
Higher-order clustering of the transmembrane anchor of DR5 drives signaling
Receptor clustering on the cell membrane is critical in the signaling of many
immunoreceptors, and this mechanism has previously been attributed to the extracellular …
immunoreceptors, and this mechanism has previously been attributed to the extracellular …
Influenza hemagglutinin membrane anchor
DJ Benton, A Nans, LJ Calder… - Proceedings of the …, 2018 - National Acad Sciences
Viruses with membranes fuse them with cellular membranes, to transfer their genomes into
cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved …
cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved …
[HTML][HTML] Helix-helix interactions in membrane domains of bitopic proteins: Specificity and role of lipid environment
Interaction between transmembrane helices often determines biological activity of
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …
Convergence and sampling in determining free energy landscapes for membrane protein association
Potential of mean force (PMF) calculations are used to characterize the free energy
landscape of protein–lipid and protein–protein association within membranes. Coarse …
landscape of protein–lipid and protein–protein association within membranes. Coarse …
A Rigorous Framework for Calculating Protein–Protein Binding Affinities in Membranes
Calculating the binding free energy of integral transmembrane (TM) proteins is crucial for
understanding the mechanisms by which they recognize one another and reversibly …
understanding the mechanisms by which they recognize one another and reversibly …
De novo-designed transmembrane domains tune engineered receptor functions
A Elazar, NJ Chandler, AS Davey, JY Weinstein… - Elife, 2022 - elifesciences.org
De novo-designed receptor transmembrane domains (TMDs) present opportunities for
precise control of cellular receptor functions. We developed a de novo design strategy for …
precise control of cellular receptor functions. We developed a de novo design strategy for …