The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or
TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The …

Cell death is an essential process that plays a vital role in restoring and maintaining skin
homeostasis. It supports recovery from acute injury and infection and regulates barrier …

Limonoids, as the vital bioactive chemical compounds in genus Melia plants, have attracted
significant attention owing to their exclusive structural characteristics and remarkable …

Abstract The cysteine protease, caspase-8, undergoes dimerization, processing, and
activation following stimulation of cells with death ligands such as TRAIL, and mediates …

Fas-associated protein with death domain (FADD), procaspase-8, and cellular FLICE-
inhibitory proteins (cFLIP) assemble through death-effector domains (DEDs), directing death …

Caspase-8 performs initiatory functions during the induction of apoptosis through the
extrinsic pathway. Apoptosis is a type of programmed cell death that plays an important role …

The assembly of death-inducing signaling complex (DISC) for activation of initiator caspase
is a key step for the receptor-mediated apoptosis signaling. Many death effector domain …

The activation of caspases is a crucial event and an indicator of programmed cell death, also
known as apoptosis. These enzymes play a central role in cancer biology and are …

Objectives Intrinsic apoptosis, which is regulated by Bcl‐2 family proteins, has an important
role in chronic inflammatory diseases. The aim of the study was to identify the tissue levels …

The role of death domain (DD) protein-mediated inter-protein interactions in cell death and
immune cell signaling have been extensively investigated as they are tentative targets for …