Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …

We have previously reported on classes of compounds that can interfere with bioassays via
a number of different mechanisms and termed such compounds Pan Assay INterference …

Background Most patients with low-grade upper tract urothelial cancer are treated by radical
nephroureterectomy. We aimed to assess the safety and activity of a non-surgical treatment …

Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing
a unique yet essential selenocysteine residue at their C‐terminus. TrxRs, together with their …

Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …

Significance: Thioredoxin (Trx) and thioredoxin reductase are two core members of the Trx
system. The system bridges the gap between the universal reducing equivalent NADPH and …

Naphthoquinones are the most commonly occurring type of quinones in nature. They are a
diverse family of secondary metabolites that occur naturally in plants, lichens and various …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

Abstract Thioredoxin reductase 2 (TrxR2) is a key component of the mitochondrial
thioredoxin system able to transfer electrons to peroxiredoxin 3 (Prx3) in a reaction mediated …

Thioredoxin plays a crucial role in a wide number of physiological processes, which span
from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics …