• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM),
which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart …

Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
emerged as a powerful tool for disease modeling, though their immature nature currently …

Cardiac contraction occurs due to the cyclical interaction between sarcomeric thin and thick
filament proteins within the cardiomyocyte. The thin filament consists of the proteins actin …

Understanding the penetrance of pathogenic variants identified as secondary findings (SFs)
is of paramount importance with the growing availability of genetic testing. We estimated …

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by unexplained left
ventricular hypertrophy and is classically caused by pathogenic or likely pathogenic variants …

Hereditary hypertrophic cardiomyopathy (HCM), due to mutations in sarcomere proteins,
occurs in more than 1/500 individuals and is the leading cause of sudden cardiac death in …

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is an important cause of sudden
cardiac death associated with heterogeneous phenotypes, but there is no systematic …

BACKGROUND: Aotearoa/New Zealand has a multiethnic population. Patients with
hypertrophic cardiomyopathy (HCM) are enrolled in the national Cardiac Inherited Diseases …