Advanced pharmaceutical applications of hot-melt extrusion coupled with fused deposition modelling (FDM) 3D printing for personalised drug delivery

DK Tan, M Maniruzzaman, A Nokhodchi - Pharmaceutics, 2018 - mdpi.com
Three-dimensional printing, also known as additive manufacturing, is a fabrication process
whereby a 3D object is created layer-by-layer by depositing a feedstock material such as …

Systematic screening of pharmaceutical polymers for hot melt extrusion processing: A comprehensive review

R Thakkar, R Thakkar, A Pillai, EA Ashour… - International journal of …, 2020 - Elsevier
Pharmaceutical research, whether industrial or academic, has attempted to adopt
approaches most efficient for the development of innovations. With the abundance of …

Compritol 888 ATO: a multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals

MH Aburahma, SM Badr-Eldin - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Compritol® 888 ATO is a lipid excipient that is generally used in cosmetic
industry as a surfactant, emulsifying agent and viscosity-inducing agent in emulsions or …

Development and optimisation of novel polymeric compositions for sustained release theophylline caplets (PrintCap) via FDM 3D printing

DK Tan, M Maniruzzaman, A Nokhodchi - Polymers, 2019 - mdpi.com
This study reports a thorough investigation combining hot-melt extrusion technology (HME)
and a low-cost fused deposition modelling (FDM) 3D printer as a continuous fabrication …

Solid lipid excipients as matrix agents for sustained drug delivery

Y Rosiaux, V Jannin, S Hughes… - Excipient Applications in …, 2015 - Springer
Lipid excipients are attracting interest from drug developers due to their performance, ease
of use, versatility and their potential to generate intellectual property through innovation in …

Solvent-free melting techniques for the preparation of lipid-based solid oral formulations

K Becker, S Salar-Behzadi, A Zimmer - Pharmaceutical Research, 2015 - Springer
Lipid excipients are applied for numerous purposes such as taste masking, controlled
release, improvement of swallowability and moisture protection. Several melting techniques …

Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters

M Maniruzzaman, A Nokhodchi - Drug discovery today, 2017 - Elsevier
Highlights•HME can be exploited in a broad range of applications for advanced drug
delivery.•Unique advantages to be utilized in a solvent free manufacturing platform.•A …

[HTML][HTML] Recent advancements in additive manufacturing techniques employed in the pharmaceutical industry: A bird's eye view

R Varghese, S Salvi, P Sood, J Karsiya… - Annals of 3D printed …, 2022 - Elsevier
Abstract The 3–dimensional printing process (3DP) was patented in the 1980s, but the
utilization of this process has expanded substantially over the past decade, to which the …

Amorphous solid dispersions or prodrugs: complementary strategies to increase drug absorption

ACF Rumondor, SS Dhareshwar… - Journal of pharmaceutical …, 2016 - Elsevier
Maximizing oral bioavailability of drug candidates represents a challenge in the
pharmaceutical industry. In recent years, there has been an increase in the use of …

[HTML][HTML] Development and evaluation of lafutidine solid dispersion via hot melt extrusion: Investigating drug-polymer miscibility with advanced characterisation

R Fule, P Amin - asian journal of pharmaceutical sciences, 2014 - Elsevier
In current study, immediate release solid dispersion (SD) formulation of antiulcer drug
lafutidine (LAFT) was developed using hot melt extrusion (HME) technique. Amphiphilic …