Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …

Sirtuins are NAD+-dependent enzymes that regulate a large number of cellular pathways
and are related to aging and age-associated diseases. In recent years, the role of sirtuins in …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as
an electron carrier in cellular metabolism and plays a crucial role in the maintenance of …

Emerging evidence demonstrates that the dysregulated metabolic enzymes can accelerate
tumorigenesis and progression via both metabolic and nonmetabolic functions. Further …

Partial denitrification granular sludge (PDGS) and denitrification granular sludge (DGS) play
an important role in nitrogen removal from wastewater. However, the inherent cause of …

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial
DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate …

Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-
dependent post-translational modification that is found on proteins as well as on nucleic …

Accumulating evidence suggests that active maintenance of optimal levels of the essential
pyridine nucleotide, nicotinamide adenine dinucleotide (NAD+) is beneficial in conditions of …

Levels of nicotinamide adenine dinucleotide (NAD+) are known to decline with age and
have been associated with impaired mitochondrial function leading to neurodegeneration, a …