[HTML][HTML] Reassessing the host defense peptide landscape
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
The immunology of host defence peptides: beyond antimicrobial activity
Host defence peptides (HDPs) are short, cationic amphipathic peptides with diverse
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
The Alzheimer's disease-associated amyloid β-protein is an antimicrobial peptide
SJ Soscia, JE Kirby, KJ Washicosky, SM Tucker… - PloS one, 2010 - journals.plos.org
Background The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's
disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct …
disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct …
Alarmins: awaiting a clinical response
JK Chan, J Roth, JJ Oppenheim… - The Journal of …, 2012 - Am Soc Clin Investig
Alarmins are endogenous molecules that are constitutively available and released upon
tissue damage and activate the immune system. Current evidence indicates that …
tissue damage and activate the immune system. Current evidence indicates that …
Exploring the human hair follicle microbiome
MB Lousada, T Lachnit, J Edelkamp… - British Journal of …, 2021 - academic.oup.com
Human hair follicles (HFs) carry complex microbial communities that differ from the skin
surface microbiota. This likely reflects that the HF epithelium differs from the epidermal …
surface microbiota. This likely reflects that the HF epithelium differs from the epidermal …
The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs
K Kuroda, K Okumura, H Isogai, E Isogai - Frontiers in oncology, 2015 - frontiersin.org
Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …
Host defense peptides and their antimicrobial-immunomodulatory duality
L Steinstraesser, U Kraneburg, F Jacobsen… - Immunobiology, 2011 - Elsevier
Host defence peptides (HDPs) are short cationic molecules produced by the immune
systems of most multicellular organisms and play a central role as effector molecules of …
systems of most multicellular organisms and play a central role as effector molecules of …
The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells
SB Coffelt, FC Marini, K Watson… - Proceedings of the …, 2009 - National Acad Sciences
Bone marrow-derived mesenchymal stem cells or multipotent mesenchymal stromal cells
(MSCs) have been shown to engraft into the stroma of several tumor types, where they …
(MSCs) have been shown to engraft into the stroma of several tumor types, where they …
Tumor microenvironment: bone marrow-mesenchymal stem cells as key players
P Barcellos-de-Souza, V Gori, F Bambi… - Biochimica et Biophysica …, 2013 - Elsevier
Tumor progression is a multistep phenomenon in which tumor-associated stromal cells
perform an intricate cross-talk with tumor cells, supplying appropriate signals that may …
perform an intricate cross-talk with tumor cells, supplying appropriate signals that may …
Cathelicidin LL-37: a multitask antimicrobial peptide
R Bucki, K Leszczyńska, A Namiot… - Archivum immunologiae et …, 2010 - Springer
The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of
peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential …
peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential …