Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Tumour cells release an abundance of microvesicles containing a selected set of proteins
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Colorectal cancer (CRC) is a heterogeneous disease in which unique subtypes are
characterized by distinct genetic and epigenetic alterations. Here we performed …

Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-
suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may …