[HTML][HTML] Artificial intelligence and statistical methods for stratification and prediction of progression in amyotrophic lateral sclerosis: A systematic review
Abstract Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative
disorder characterised by the progressive loss of motor neurons in the brain and spinal cord …
disorder characterised by the progressive loss of motor neurons in the brain and spinal cord …
[HTML][HTML] Neurometabolic alterations in motor neuron disease: insights from magnetic resonance spectroscopy
F Christidi, E Karavasilis, GD Argyropoulos… - Journal of integrative …, 2022 - imrpress.com
Magnetic resonance spectroscopy (MRS) has contributed important academic insights in
motor neuron diseases (MNDs), particularly in amyotrophic lateral sclerosis (ALS). Over the …
motor neuron diseases (MNDs), particularly in amyotrophic lateral sclerosis (ALS). Over the …
Phenotypic categorisation of individual subjects with motor neuron disease based on radiological disease burden patterns: A machine-learning approach
Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
[HTML][HTML] Deep learning methods to predict amyotrophic lateral sclerosis disease progression
Amyotrophic lateral sclerosis (ALS) is a highly complex and heterogeneous
neurodegenerative disease that affects motor neurons. Since life expectancy is relatively …
neurodegenerative disease that affects motor neurons. Since life expectancy is relatively …
[HTML][HTML] Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker …
Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …
management implications. The objective of this study is the longitudinal evaluation of a large …
[HTML][HTML] Pathological neural networks and artificial neural networks in ALS: diagnostic classification based on pathognomonic neuroimaging features
P Bede, A Murad, O Hardiman - Journal of neurology, 2021 - Springer
The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …
academically important, but the practical demands of clinical neurology centre on the …
[HTML][HTML] Clusters of anatomical disease-burden patterns in ALS: a data-driven approach confirms radiological subtypes
P Bede, A Murad, J Lope, O Hardiman, KM Chang - Journal of neurology, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …
[HTML][HTML] Hippocampal metabolic alterations in amyotrophic lateral sclerosis: a magnetic resonance spectroscopy study
F Christidi, GD Argyropoulos, E Karavasilis… - Life, 2023 - mdpi.com
Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis
(ALS) has been overwhelmingly applied to motor regions to date and our understanding of …
(ALS) has been overwhelmingly applied to motor regions to date and our understanding of …
[HTML][HTML] Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers
Background The characterisation of presymptomatic disease-burden patterns in
asymptomatic mutation carriers has a dual academic and clinical relevance. The …
asymptomatic mutation carriers has a dual academic and clinical relevance. The …
[HTML][HTML] Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs
Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …