The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …

The use of anti-diabetic drugs has been increasing worldwide and the evolution of
therapeutics has been enormous. Still, the currently available anti-diabetic drugs do not …

A highly efficient di-C-glycosyltransferase GgCGT was discovered from the medicinal plant
Glycyrrhiza glabra. GgCGT catalyzes a two-step di-C-glycosylation of flopropione-containing …

Bioactive natural C-glycosides are rare and chemical C-glycosylation faces challenges
while enzymatic C-glycosylation catalyzed by C-glycosyltransferases provides an alternative …

Mitochondria are the primary source of energy production in the brain thereby supporting
most of its activity. However, mitochondria become inefficient and dysfunctional with age and …

Aspalathin is a C-glucosyl dihydrochalcone that is abundantly present in Aspalathus
linearis. This endemic South African plant, belonging to the Cape Floristic region, is normally …

Dihydrochalcones are a class of secondary metabolites, for which demand in biological and
pharmacological applications is still growing. They posses several health-endorsing …

In the pursuit of bioactive phytochemicals as a therapeutic strategy to manage metabolic risk
factors for type 2 diabetes (T2D), aspalathin, C-glucosyl dihydrochalcone from rooibos …

Gliflozins constitute an important class of compounds useful as sodium glucose co-
transporter (SGLT2) inhibitors to treat type-II diabetes. They act by blocking sodium-glucose …

Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's
disease, and diabetes-induced dementia, there are no disease-modifying therapies that are …