Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals,
including renal hemodynamics, neuroendocrine, and cardiovascular functions. Collectively …

ATRIAL natriuretic peptide (ANP) is a polypeptide hormone whose effects include the
induction of diuresis, natriuresis and vasorelaxation1. One of the earliest events following …

Atrial natriuretic peptide (ANP) binds directly to a plasma membrane form of guanylate
cyclase (GCA), stimulating the production of the second messenger cyclic GMP. We show …

We have examined the effects of the natriuretic peptides on DNA synthesis in primary
cultures of neonatal rat cardiac fibroblasts. Binding analysis using 125I-labeled atrial …

A plasma membrane form of guanylate cyclase is a cell surface receptor for atrial natriuretic
peptide (ANP). In response to ANP binding, the receptor-enzyme produces increased …

We have recently shown that atrial natriuretic factor (ANF) inhibits adenylate cyclase activity
in rat platelets where only one population of ANF receptors (ANF-R2) is present, indicating …

Here, we report the design of unprecedented, non-FRET based cGMP-biosensors, named
FlincGs, to assess the dynamics of nitric oxide (NO) and atrial natriuretic peptide (ANP) …

Clearance (C) receptors of atrial natriuretic factor (ANF) have an important role of removing
ANF from the circulation. In the present study we investigated the cellular mechanisms of this …

The discovery of atrial, brain, and C-type natriuretic peptides (ANP, BNP, and CNP) and their
cognate receptors has greatly increased our knowledge of the control of hypertension and …

Soluble guanylate cyclase purified from rat lung exists as a heterodimer of two subunits (70
kDa and 82 kDa). Recent cloning and sequencing of both subunit entities have revealed …