[HTML][HTML] The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer
D Ramesh-Kumar, S Guil - Seminars in Cancer Biology, 2022 - Elsevier
RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …
mechanisms to modulate the transcriptional output and respond to changing cellular …
IGF2BP3 from physiology to cancer: novel discoveries, unsolved issues, and future perspectives
C Mancarella, K Scotlandi - Frontiers in cell and developmental …, 2020 - frontiersin.org
RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …
Updated protein domain annotation of the PARP protein family sheds new light on biological function
MJ Suskiewicz, D Munnur, Ø Strømland… - Nucleic Acids …, 2023 - academic.oup.com
AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …
through their ability to accurately predict protein structures. In the present work, we explored …
IGF2BP3 promotes mRNA degradation through internal m7G modification
Recent studies have suggested that mRNA internal m7G and its writer protein METTL1 are
closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP …
closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP …
First small-molecule inhibitors targeting the RNA-binding protein IGF2BP2/IMP2 for cancer therapy
C Dahlem, A Abuhaliema, SM Kessler… - ACS chemical …, 2022 - ACS Publications
The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns
S Ebersberger, C Hipp, MM Mulorz, A Buchbender… - Molecular cell, 2023 - cell.com
Splicing of pre-mRNAs critically contributes to gene regulation and proteome expansion in
eukaryotes, but our understanding of the recognition and pairing of splice sites during …
eukaryotes, but our understanding of the recognition and pairing of splice sites during …
IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism
H Hornegger, AS Anisimova, A Muratovic… - Nature …, 2024 - nature.com
The insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) is a conserved RNA-
binding protein that regulates RNA stability, localization and translation. IGF2BP1 is part of …
binding protein that regulates RNA stability, localization and translation. IGF2BP1 is part of …
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression
Y Zhang, L Zhao, S Yang, Y Cen, T Zhu, L Wang… - Journal of experimental …, 2020 - Springer
Abstract Background Circular RNAs (circRNAs) have been reported to play key roles in the
development of various cancers. However, the biological functions and clinical significance …
development of various cancers. However, the biological functions and clinical significance …
[HTML][HTML] Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating β-catenin signaling
D Song, J Shang, Y Long, M Zhong, L Li, J Chen… - Jci Insight, 2023 - ncbi.nlm.nih.gov
Wnt/β-catenin is a developmental signaling pathway that plays a crucial role in driving
kidney fibrosis after injury. Activation of β-catenin is presumed to be regulated through the …
kidney fibrosis after injury. Activation of β-catenin is presumed to be regulated through the …
The biological function of IGF2BPs and their role in tumorigenesis
QY Du, ZM Zhu, DS Pei - Investigational new drugs, 2021 - Springer
The insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) pertain to a highly
conservative RNA-binding family that works as a post-transcriptional fine-tuner for target …
conservative RNA-binding family that works as a post-transcriptional fine-tuner for target …