Immunosuppressive agents and infectious risk in transplantation: managing the “net state of immunosuppression”

MB Roberts, JA Fishman - Clinical Infectious Diseases, 2021 - academic.oup.com
Successful solid organ transplantation reflects meticulous attention to the details of
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …

Microbial transmission in animal social networks and the social microbiome

A Sarkar, S Harty, KVA Johnson, AH Moeller… - Nature ecology & …, 2020 - nature.com
Host-associated microbiomes play an increasingly appreciated role in animal metabolism,
immunity and health. The microbes in turn depend on their host for resources and can be …

Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation

JC Swarte, Y Li, S Hu, JR Björk, R Gacesa… - Science Translational …, 2022 - science.org
Organ transplantation is a life-saving treatment for patients with end-stage disease, but
survival rates after transplantation vary considerably. There is now increasing evidence that …

Engineering immunomodulatory biomaterials for type 1 diabetes

CL Stabler, Y Li, JM Stewart… - Nature Reviews Materials, 2019 - nature.com
A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …

Antibiotic pretreatment alleviates liver transplant damage in mice and humans

K Nakamura, S Kageyama, T Ito… - The Journal of …, 2019 - Am Soc Clin Investig
Although modifications of gut microbiota with antibiotics (Abx) influence mouse skin and
cardiac allografts, its role in orthotopic liver transplantation (OLT) remains unknown. We …

Gut microbial metabolites induce donor-specific tolerance of kidney allografts through induction of T regulatory cells by short-chain fatty acids

H Wu, J Singer, TK Kwan, YW Loh… - Journal of the …, 2020 - journals.lww.com
Background Short-chain fatty acids derived from gut microbial fermentation of dietary fiber
have been shown to suppress autoimmunity through mechanisms that include enhanced …

Shared and distinctive features of the gut microbiome of C57BL/6 mice from different vendors and production sites, and in response to a new vivarium

LL Long, KL Svenson, AJ Mourino, M Michaud… - Lab animal, 2021 - nature.com
Animal models play a critical role in establishing causal relationships between gut
microbiota and disease. The laboratory mouse is widely used to study the role of microbes in …

The gut microbiota in transplant patients

PP Chong, AY Koh - Blood reviews, 2020 - Elsevier
Solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients are
at increased risk for developing infections due to underlying immunosuppression. Antibiotic …

Enterococcus faecium Modulates the Gut Microbiota of Broilers and Enhances Phosphorus Absorption and Utilization

W Wang, H Cai, A Zhang, Z Chen, W Chang, G Liu… - Animals, 2020 - mdpi.com
Simple Summary Bone health is an important factor in broiler production. Among the key
nutrients affecting bone health, phosphorus (P) plays a great role. Enterococcus faecium has …

The gut microbiome in solid organ transplantation

M Baghai Arassi, G Zeller, N Karcher… - Pediatric …, 2020 - Wiley Online Library
Despite ground‐breaking advances in allogeneic transplantation, allograft rejection and
immunosuppressant‐specific complications remain a major challenge in transplant …