[HTML][HTML] Natural compounds as inhibitors of Aβ peptide aggregation: chemical requirements and molecular mechanisms

K Pagano, S Tomaselli, H Molinari… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …

Chemical and structural features influencing the biological activity of curcumin

K Indira Priyadarsini - Current pharmaceutical design, 2013 - ingentaconnect.com
Curcumin, a polyphenolic natural product, exhibits therapeutic activity against a number of
diseases, attributed mainly to its chemical structure and unique physical, chemical, and …

Curcumin- and Fish Oil-Loaded Spongosome and Cubosome Nanoparticles with Neuroprotective Potential against H2O2-Induced Oxidative Stress in Differentiated …

M Rakotoarisoa, B Angelov, VM Garamus… - ACS …, 2019 - ACS Publications
Many phytochemical antioxidant compounds, including curcumin (CU), are water-insoluble
and thus require delivery carriers in order to increase their bioavailability for in vivo …

[HTML][HTML] Exploring the therapeutic potential of phytochemicals in Alzheimer's disease: Focus on polyphenols and monoterpenes

I Piccialli, V Tedeschi, L Caputo, S D'Errico… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …

Curcumin in Alzheimer's disease: Can we think to new strategies and perspectives for this molecule?

MM Serafini, M Catanzaro, M Rosini, M Racchi… - Pharmacological …, 2017 - Elsevier
Population aging is an irreversible global trend with economic and socio-political
consequences. One of the most invalidating outcomes of aging in the elderly is cognitive …

Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease

B Le Droumaguet, J Nicolas, D Brambilla, S Mura… - ACS …, 2012 - ACS Publications
A versatile and efficient functionalization strategy for polymeric nanoparticles (NPs) has
been reported and successfully applied to PEGylated, biodegradable poly (alkyl …

Amphiphilic nanocarrier systems for curcumin delivery in neurodegenerative disorders

M Rakotoarisoa, A Angelova - The Road from Nanomedicine to …, 2019 - taylorfrancis.com
Neurodegenerative diseases are disabling chronic disorders characterized by the
progressive loss of neurons in different areas of the central nervous system …

Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline

OM Dumitrascu, PD Lyden, T Torbati… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Despite advances in imaging retinal amyloidosis, a quantitative and
topographical investigation of retinal amyloid beta burden in patients with cognitive decline …

Recent developments in chemistry and biology of curcumin analogues

K Bairwa, J Grover, M Kania, SM Jachak - RSC advances, 2014 - pubs.rsc.org
Curcumin, a prominent constituent of the rhizome of Curcuma longa L., possesses versatile
biological properties, which is evidenced from the extensive research during the last half …

Amyloid β-peptide 25–35 self-assembly and its inhibition: A model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease …

M Naldi, J Fiori, M Pistolozzi, AF Drake… - ACS chemical …, 2012 - ACS Publications
Combined results of theoretical molecular dynamic simulations and in vitro spectroscopic
(circular dichroism and fluorescence) studies are presented, providing the atomistic and …