Biochemistry and molecular biology of flaviviruses
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical
technique being increasingly applied to a wide variety of problems. As the HDX-MS …
technique being increasingly applied to a wide variety of problems. As the HDX-MS …
SARS-CoV-2 S protein: ACE2 interaction reveals novel allosteric targets
The Spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface
ACE2 receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here …
ACE2 receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here …
Advances in hydrogen/deuterium exchange mass spectrometry and the pursuit of challenging biological systems
EI James, TA Murphree, C Vorauer, JR Engen… - Chemical …, 2021 - ACS Publications
Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …
a widespread tool for structural analysis across academia and the biopharmaceutical …
Pathogenesis and virulence of flavivirus infections
The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …
Physics of viral dynamics
Viral capsids are often regarded as inert structural units, but in actuality they display
fascinating dynamics during different stages of their life cycle. With the advent of single …
fascinating dynamics during different stages of their life cycle. With the advent of single …
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics
SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows
multiple mutations predominantly localized to the spike (S) protein. Here, amide …
multiple mutations predominantly localized to the spike (S) protein. Here, amide …
Contemporary hydrogen deuterium exchange mass spectrometry
I Oganesyan, C Lento, DJ Wilson - Methods, 2018 - Elsevier
Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) emerged as a tool for
biochemistry and structural biology around 25 years ago. It has since become a key …
biochemistry and structural biology around 25 years ago. It has since become a key …
Current status and perspectives on vaccine development against dengue virus infection
J Park, J Kim, YS Jang - Journal of Microbiology, 2022 - Springer
Dengue virus (DENV) consists of four serotypes in the family Flaviviridae and is a causative
agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. DENV is …
agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. DENV is …
Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions
E Trabjerg, ZE Nazari, KD Rand - TrAC Trends in Analytical Chemistry, 2018 - Elsevier
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has within the last 25 years
evolved to become a well-established technique for analysing the solution-phase …
evolved to become a well-established technique for analysing the solution-phase …